Widespread Hypertrophic Lichen Planus following Programmed Cell Death Ligand 1 Blockade
نویسندگان
چکیده
منابع مشابه
Squamous cell carcinoma in hypertrophic lichen planus.
Neoplastic transformation (development of squamous cell carcinoma / verrucous carcinoma) in lichen planus has been described, especially in the oral form of the disease where an estimated 0.3-3% of patients may develop squamous cell carcinoma. Malignancy though uncommon with cutaneous lichen planus has been described in chronic hypertrophic lesions of lichen planus on the legs, including a case...
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Early phase clinical trials targeting the programmed death receptor-1/ligand-1 (PD-1/PD-L1) pathway to overcome tumor-mediated immunosuppression have reported promising results for a variety of cancers. This pathway appears to play an important role in the failure of immune reactivity to malignant plasma cells in multiple myeloma patients, as the tumor cells express relatively high levels of PD...
متن کاملSquamous Cell Carcinoma Arising from Hypertrophic Lichen Planus
Lichen planus is not a common premalignant condition; a study showed only 8 SCC developing in 2071 patients of lichen planus followed up for over 9.9 years.[1] LPH and oral lichen planus are two variants which have a higher risk of malignant transformation. Till December 2015, 38 cases of SCC developing in LPH have been reported.[2] SCC arising from LPH is most commonly seen on the lower limbs,...
متن کاملTwice malignant transformation of hypertrophic lichen planus.
Lichen planus is a chronic mucocutaneous T-cell-mediated disease, the cause of which remains unknown. The first case of lichen planus that transformed into squamous cell carcinoma was reported in 1903. The presented study concerns the case of a 62-year-old woman in whom twice malignant transformation of hypertrophic lichen planus in the dorsal part of the left foot developed. Several studies ha...
متن کاملHypertrophic lichen planus mimicking squamous cell carcinoma of skin.
735 The Journal of the American Osteopathic Association September 2014 | Vol 114 | No. 9 A purple pruritic plaque of the right leg developed in a 56-year-old woman with migraine headaches. Similar lesions appeared subsequently on all extremities within 3 months. At presentation, numerous plaques with scales (pictured) were observed overlying both upper and lower extremities and plantar surfaces...
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ژورنال
عنوان ژورنال: Case Reports in Dermatology
سال: 2020
ISSN: 1662-6567
DOI: 10.1159/000508490